Objective
Impaired mitochondrial energy metabolism is recognized as an increasingly relevant cause of human disability in Europe, especially for infants and children.
Besides mutations in the mitochondrial genome, mitochondrial disorders can be the consequence of mutations in numerous nuclear genes encoding factors involved in mtDNA maintenance and expression, and in the formation and regulation of the mitochondrial respiratory chain (MRC). In particular, mutations in genes encoding factors controlling the assembly o f MRC are responsible for severe, early-onset mitochondrial syndromes.
However, in spite of the wealth of information gathered in recent years on the genetic basis of these disorders, neither the detailed molecular mechanisms leading to cell or tissue failure are known, nor are the metabolic consequences ultimately determining the clinical phenotype, completely understood.
The aim of this project is to allow Dr. Erika Fernandez-Vizarra, a researcher with experience in Biochemistry and Molecular and Cellular Biology, to undertake training through research at the Istituto Nazionale Neurologico Carlo Besta in Milan, Italy, with a view to completing her expertise in the mechanisms of formation, structural modulation and functional control of MRC and mitochondria l homeostasis.
In collaboration with the host, she will shed light on the normal function of, and pathogenic mechanisms due to mutations in three disease-associated MRC assembly factors, Surf1, BCS1L and COX15.
The project will be implemented via a multidisciplinary approach including in vitro characterization of mitochondrial proteins, cell biology and cell imaging on normal and mutant cell lines, and in vivo studies based on the creation and investigation of recombinant animals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine nephrology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences chemical sciences organic chemistry amines
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.