Objective
Since the completion of the human and other organisms' genome sequence, many new druggable targets are expected to be identified by structural genomics with the expectation of developing new therapeutics. One of the bottlenecks of this drug discovery process is the difficulties encountered to understand the function of these new proteins. So far, much emphasis has been given to bioinformatics: the genomes are annotated using sequence analysis or structural modelling. However, these methods are not always applicable or relevant.
This proposal suggests to investigate methods derived from chemoinformatics. Specifically, chemogenomics implies that the function of a protein can be derived from the structure of the sets of ligands that bind to it. By comparing the pair-wise similarity of these sets of compounds to random distributions, statistical models can be used to compute scores between pairs of sets. These scores are then used to build chemical relationship maps, i.e. ontology of the ligands. These maps could be used alternatively or complementarily to other classifications to annotate the genomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences computer and information sciences knowledge engineering ontology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences mathematics applied mathematics statistics and probability
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
STRASBOURG
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.