Objective
The proposed research plans to understand the relationship between structural requirements for TCR/peptide/MHC interactions and their influence on TCR repertoire diversity given it has been reported that increased T cell repertoire diversity correlates with increased resistance to viral infection. While the structural characteristics of TCR/peptide/MHC interactions can be elucidated, a large question that remains is how these factors influence the function of virus-specific CTL generated after infection.
This proposal aims to first study the molecular interactions that define specific TCR recognition of both DbNP366 and DbPA224 complexes (respiratory infection of C57BL/6J (H-2b) mice with influenza A viruses induces CD8+ T cell responses specific for epitopes derived from nucleoprotein amino acid 366-374 and acidic polymerase amino acid 224-233 with structural and functional differences). The second aim utilises a retroviral transduction system to ectopically express TCRs of known specificity. This will facilitate the analysis of functional characteristics of these transduced T cells after infection. In this way, this proposal will link the structural aspects of TCR recognition of peptide/MHC complexes and the in vivo consequences these interactions have on the responding T cell repertoire. These studies will provide a rationale for vaccine design human viral pathogens such as HIV, Hepatitis C and Influenza A virus.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
32116 NANTES
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.