Objective
While the molecular mechanisms underlying transcriptional activation have been disected to a large extent, transcriptional repression remains poorly understood. To further our knowledge about the mechanisms of transcriptional repression I have been using two molecular models: 1) the retinoblastoma protein (Rb), a key regulator of cell cycle and 2) ZEB proteins (ZEB1/deltaEF1 and ZEB2/SIP1), an emerging family of transcription factors that regulates development and cell differentiation. ZEB proteins bind to a subset of E box sequences in the promoter region of target genes to repress gene expression in several tissues.
In the present research proposal I intend to further dissect the mechanisms of transcriptional repression to gain understanding not only on the role of repression during cell differentiation in physiological conditions but, and more importantly, during pathological processes such as cancer. The lines of work proposed hereafter are: 1) study the regulation of the TGFbeta/BMP signalling pathway by ZEB proteins. 2) characterize how ZEB proteins repress gene expression through modifications of the chromatin structure and 3) further our understanding of the ZEB proteins in cell differentiation and malignant transformation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine oncology leukemia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
BARCELONA.
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.