Obiettivo While the molecular mechanisms underlying transcriptional activation have been disected to a large extent, transcriptional repression remains poorly understood. To further our knowledge about the mechanisms of transcriptional repression I have been using two molecular models: 1) the retinoblastoma protein (Rb), a key regulator of cell cycle and 2) ZEB proteins (ZEB1/deltaEF1 and ZEB2/SIP1), an emerging family of transcription factors that regulates development and cell differentiation. ZEB proteins bind to a subset of E box sequences in the promoter region of target genes to repress gene expression in several tissues.In the present research proposal I intend to further dissect the mechanisms of transcriptional repression to gain understanding not only on the role of repression during cell differentiation in physiological conditions but, and more importantly, during pathological processes such as cancer. The lines of work proposed hereafter are: 1) study the regulation of the TGFbeta/BMP signalling pathway by ZEB proteins. 2) characterize how ZEB proteins repress gene expression through modifications of the chromatin structure and 3) further our understanding of the ZEB proteins in cell differentiation and malignant transformation. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepathologymedical and health sciencesclinical medicineoncologyleukemia Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-4.2 - Marie Curie International Reintegration Grants (IRG) Invito a presentare proposte FP6-2004-MOBILITY-12 Vedi altri progetti per questo bando Meccanismo di finanziamento IRG - Marie Curie actions-International re-integration grants Coordinatore INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER Contributo UE Nessun dato Indirizzo Villarroel, 170 BARCELONA. Spagna Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
