Objective
The establishment and maintenance of cellular polarity are critical for organ function. In addition to the ubiquitous apicobasal axis, many epithelial cells display a second polarity axis within the plane of the tissue, referred to as planar cell polarity. The orientation of hair-cell stereocilia in the inner ear represents a striking example of planar polarity in vertebrates. Although many of the proteins involved in the interpretation of the polarising cues have been identified, the mechanistic bases of t heir activity are not known.
The motivation of this project is to understand the molecular and cellular mechanisms that generate the precise architecture of a sensory epithelium, with an emphasis on planar cell polarity. Hair cells provide an excellent mod el for cell-polarity studies. Experiments will be done using the anatomically simple mechanosensory organs of the lateral line in the zebrafish, whose hair cells display a stereotyped planar polarity pattern. I will first investigate the cellular mechanism s that lead to the planar polarisation of hair cells during lateral-line development. Second, I will study how the polarised organisation is recovered after hair-cell regeneration.
Preliminary evidence suggests that functional properties of progenitor cell s within the organ are determinants of hair-cell polarisation. I shall test this hypothesis by tracking protein localisation patterns during hair-cell development in vivo, in wild type and mutant specimens with randomised planar polarity. To facilitate the se analysis, I will use transgenic reporter lines with specific expression in the lateral line, in combination with fluorescently tagged proteins that distribute asymmetrically in hair cells. This innovative approach shall lead to a deeper understanding of the mechanisms governing the formation and repair of sensory organs in vertebrates, a process that I plan to explore further as an independent investigator.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell polarity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.