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Non-linear analysis of dynamic interactions between brain areas

Final Activity Report Summary - NADIBA (Non-linear analysis of dynamic interactions between brain areas)

The way the brain areas communicate during different mental tasks or under specific conditions, or the way they interact with different physiological control systems is not yet clarified. The NADIBA project contributed to the understanding of communication within the brain areas by proposing some methods to reveal the cerebral interactions and brain influences by means of extracting the information from event-related potentials (ERP). The functional magnetic determination of how brain areas communicated during different mental tasks or under specific conditions, or how they interacted under different physiological control systems was not yet clarified.

NADIBA contributed to the understanding of communication between brain areas by proposing methods which revealed cerebral interactions and brain influences using data from ERP, functional magnetic resonance imaging (fMRI), electroencephalogram (EEG) and cerebral blood flow (CBF). To investigate effective connectivity in the brain, the Granger causality index was applied, based on time variant and time invariant connectivity models and considering linear and non-linear models.

The principal aims of the project were to:

1. elucidate how brain areas communicated in the constitution of pain,
2. clarify how brain areas interacted during orthographic and phonological tasks in an attempt to explain difficulties of dyslexic children in executing linguistic tasks,
3. reveal the connectivity network existing between primary motor cortex (M1), supplementary motor area (SMA) and pre-supplementary motor area (preSMA) during finger tapping by means of analysis of the fMRI recordings and
4. investigate interactions between heart rate, blood pressure, cerebral blood pressure and respiration, as well as their regulation by the autonomic nervous system.