Objective
The number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be the calcium of the twenty-first century (Nature Rev. Neurosci. June 2005, vol. 6, 449-62). Up to now, Zn can be detected only in vitro and with limited accuracy, due to non-specific reaction of Zn chelators, which react also with Ca2+.
Recently, some new fluorescent probes for Zn2+ were developed with increased Zn2+ specificity. 62Zn-EDDA was the only known to me Zn radiotracer used in PET monitoring of pancreas activity in dogs. PET registration in vivo of placement and dynamics of Zn containing proteins and small molecules will not have the same resolution as in vitro, but offers many advantages, among the most important, that the animal is its own control, and it is tested alive.
I would like to develop and implement new PET radiotracer based on 62Zn, 63Zn or 65Zn that would allow in vivo registration of Zn2+ transport in the brain of small animals. The same isotopes will be used for imaging in vitro together with new Zn specific fluorescent probes.
One of the areas of application will be research on expression of matrix metalloprotease 9 (MMP-9), which contains Zn in active site and structural Zn and Ca. The role of MMP-9 in plasticity of the brain was subject of my recent neurobiological research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences chemical sciences inorganic chemistry transition metals
- agricultural sciences animal and dairy science domestic animals
- medical and health sciences basic medicine neurology stroke
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.