Objective
We propose to develop a model that unites viral population genetics and phylogenetics to investigate HIV transmission histories. This genealogy-based population genetic model will accommodate for variable population sizes within and between infected hosts, while taking into account phylogenetic relationships between the patients.
It is our objective to implement this model in a recently developed, highly flexible Bayesian framework and to validate this method on a comprehensive set of clonal sequences sampled over time from a well-documented HIV transmission chain. We aim to apply our novel approach to at least three well-characterized HIV transmission chains and to extend the application to other rapidly evolving virus populations.
This will allow us to estimate the strength and magnitude of the genetic bottleneck associated with viral transmission and to evaluate its impact on evolution at the population level. Thereby, we can address the switching of co-receptor usage within patients and the spread of immune-escape and drug resistance mutations in the HIV infected population. This research will also result in statistical methods that provide a more realistic description of viral evolution with important practical applications in viral epidemiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences public health epidemiology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.