Objective
The development of synthetic methodology using enantioselective organocatalysis promises the efficient generation of structurally diverse and functionally versatile molecules. The applications of the methodology are wide-ranging and this proposal aims to use enantioselective organocatalysis to address problems in both synthesis and chemical biology. This will offer a multi-disciplinary aspect to the proposed research and in particular we will use the molecular functionality to design cascade reactions for the innovative and rapid synthesis of bioactive natural products. Furthermore enantioselective catalysis can provide ideal building blocks the synthesis of structurally unbiased libraries that can be used to probe biological function or mode of action.
Alternatively, a more focussed approach using chemical genetics can be used to investigate biological function through the synthesis of natural product like libraries. We propose to develop an organocatalytic and enantioselective variant of this transformation that precludes the use of strong bases and avoids the competing 1,2-rearrangement and is mediated through the generation of a transient enamine motif via secondary amine catalysis. The use of homochiral substituted secondary amines should lead to the first catalytic enantioselctive sigmatropic rearrangement reaction. The potential applications of this reaction are widespread as the ability to install 2-vicinal stereo-centres embedded amongst up to 3-orthogonally reactive functional groups represents a powerful transformation. Applications to the synthesis of architecturally complex natural products will be investigated that exploit efficacy of the proposed new transformation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.