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New strategies for chemical synthesis: Enantio-selective Organocatalytic Sigmatropic rearrangements

Final Activity Report Summary - ORGANOCATALYSIS (New strategies for chemical synthesis: enantioselective organocatalytic sigmatropic rearrangements)

A new method for the rapid assembly of highly complex molecules was achieved. These molecules can be form as single stereoisomers and represent highly attractive scaffolds upon which to base the synthesis of new biological active molecules.
The method uses a small organic molecule to act as a catalyst to dearomatise and cyclise a planar aromatic molecule, converting it to a 3D architecture that has high therapeutic potential. Work is ongoing and the results will be published later this year.