Objetivo A miscellany of new strategies, experimental techniques and theoretical approaches are emerging in the ongoing battle against cancer. The objective of the proposal is to model the biomechanical behavior of tumor growth in order to verify the efficiency of anti-cancer therapeutic actions.The main purpose is to study the influence of the structural biology of tumor cells and its vascular network on the determination of the mechanical characteristics of cancerous mass growth. Experiments will be held in synergy with clinicians and biologists, performing both in-vivo and in-vitro (using multi-cell spheroids and mono-layer cultures) examinations, with the design and the fabrication of appropriate micro or nano sensing devices.Peculiar and innovative aspects of the modeling effort include:-different chemotactic sensitivities for proliferative and quiescent cells;-regenerative characteristics of hypoxic cells;-investigation of residual stresses and memory of the cancerous mass;-permeability and heterogeneities Ámbito científico medical and health sciencesclinical medicineoncologyskin cancermelanomanatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesbiophysicsnatural sciencesbiological sciencesmolecular biologystructural biology Palabras clave Mechanical properties anti-cancer therapy applied mathematics bioengineering medical physics micro- and nano-sensors residual stress statistical physics Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2005-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Aportación de la UE Sin datos Dirección 3 rue Michel-Ange PARIS Francia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
