Objective A miscellany of new strategies, experimental techniques and theoretical approaches are emerging in the ongoing battle against cancer. The objective of the proposal is to model the biomechanical behavior of tumor growth in order to verify the efficiency of anti-cancer therapeutic actions.The main purpose is to study the influence of the structural biology of tumor cells and its vascular network on the determination of the mechanical characteristics of cancerous mass growth. Experiments will be held in synergy with clinicians and biologists, performing both in-vivo and in-vitro (using multi-cell spheroids and mono-layer cultures) examinations, with the design and the fabrication of appropriate micro or nano sensing devices.Peculiar and innovative aspects of the modeling effort include:-different chemotactic sensitivities for proliferative and quiescent cells;-regenerative characteristics of hypoxic cells;-investigation of residual stresses and memory of the cancerous mass;-permeability and heterogeneities Fields of science medical and health sciencesclinical medicineoncologyskin cancermelanomanatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesbiophysicsnatural sciencesbiological sciencesmolecular biologystructural biology Keywords Mechanical properties anti-cancer therapy applied mathematics bioengineering medical physics micro- and nano-sensors residual stress statistical physics Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2005-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Address 3 rue michel-ange Paris France See on map Links Website Opens in new window EU contribution € 0,00
