A miscellany of new strategies, experimental techniques and theoretical approaches are emerging in the ongoing battle against cancer. The objective of the proposal is to model the biomechanical behavior of tumor growth in order to verify the efficiency of anti-cancer therapeutic actions.
The main purpose is to study the influence of the structural biology of tumor cells and its vascular network on the determination of the mechanical characteristics of cancerous mass growth. Experiments will be held in synergy with clinicians and biologists, performing both in-vivo and in-vitro (using multi-cell spheroids and mono-layer cultures) examinations, with the design and the fabrication of appropriate micro or nano sensing devices.
Peculiar and innovative aspects of the modeling effort include:
-different chemotactic sensitivities for proliferative and quiescent cells;
-regenerative characteristics of hypoxic cells;
-investigation of residual stresses and memory of the cancerous mass;
-permeability and heterogeneities
Call for proposal
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