Objective
Sepsis is a systemic response to an infection of the bloodstream by bacteria, which causes organ failure and death in severe cases. Annually, about 1.5 Million people worldwide suffer from sepsis and approximately 1400 people die daily from this disease. Early diagnosis and appropriate treatment can greatly improve survival rates. Currently, infectious diseases are diagnosed by studying vital signs (e.g. fever, rapid heart rate). Moreover, blood cultures are grown to detect the presence of bacteria. In general, to get results from blood culturing takes three days and a non-optimised therapy by a broad spectrum, a "cocktail" of antibiotics is started before culturing results arrive. To clearly improve the treatment of patients, rapid diagnostic clinical tests are required. Sensitive technology is envisioned to reduce the analysis time from several days to a few hours. At Philips Research we have started studies on bacterial DNA detection, based on surface-enhanced resonant Raman spectroscopy (SERRS).
SERRS enables sensitive and selective detection of molecules adsorbed at a metal surface. The scattered light consists of molecule-specific bands, which renders discrimination of multiple analytes possible. DNA of infectious bacteria is detected through the measurement of SERRS labels adsorbed at aggregated silver colloids. Advantages of SERRS are: high sensitivity (pico-molar) and the unique potential to simultaneously measure mixtures of DNA labels.
To bring the SERRS method to such a level that it can be used as clinical tool, quite some effort is required and knowledge at Philips needs to be build up, especially in the following three areas:
1. molecular biology and biochemistry,
2. colloid and surface chemistry and
3. bio-informatics, respectively.
This proposal applies for 3 ToK Fellows, 24 months each, for our molecular diagnostics SERRS project in the upper three areas.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
90050 EINDHOVEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.