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Content archived on 2024-06-16

Engineering selective elements for disposable point of test sensor chips

Objective

Globally, there is a growing problem of drug driving. It is believed that drugs of abuse contribute to up to 25% of fatal road accidents. Governments worldwide are introducing legislation for roadside testing. As yet no suitable instrument is available on the market. The routine test for the detection of drugs measures the level of metabolite in urine, which is not practicable for roadside testing nor indicates drugs taken in the last few hours. Detecting drug traces directly in oral fluid has been identified as the best roadside method of detection. There are significant challenges as the sample is small and detection levels are ppb.

A global need exists for a cheap, drugs of abuse test (DAT) using saliva for roadside use by people who are not medically trained. NanoDAT addresses these issues by introducing a technology, based on molecular imprinted polymers (MIPs), to a DAT sensor platform. MIPs can replace costly and less stable antibodies leading to mass-producible and cost-effective systems for DAT applications. The shelf life of the systems will be improved by a factor of at least ten. The basic concepts and knowledge to be developed and transferred have widespread applicability in fields outside of DAT such as clinical and environmental process control.

The main scientific and technological objective of NanoDAT is the design of a miniaturised sensor technology as a platform for detection of relevant drug analytes and their metabolites. The nanostructured biomimetic materials will overcome both the stability and short shelf life problems inherent to antibody based systems. Microfluidic devices will also be developed that need minimal sample volumes. Integrated photonic detection will provide a rapid, hand held detection technology. NanoDAT is a significantly multidisciplinary Marie Curie project with participation from chemists, computational materials scientists, physicists, microfluidic fabrication engineers and semiconductor technologists.

Fields of science (EuroSciVoc)

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Keywords

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Topic(s)

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Call for proposal

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FP6-2005-MOBILITY-3
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Funding Scheme

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TOK - Marie Curie actions-Transfer of Knowledge

Coordinator

BIOSENSIA LTD
EU contribution
No data
Address
Unit 1.16, Nova UCD UCD - University College Dublin
BELFIELD, DUBLIN 4
Ireland

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Total cost

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Participants (1)

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