Objective
Common diseases like allergy, autoimmunity and cancer are complex, i.e. caused by multiple interacting genes and environmental factors. Using high-throughput methods all genes and their products can be studied in common diseases. The challenge lies in understanding the complex gene and protein interactions that underlie these diseases. The Pathfinder project has shown that common principles, such as network theory can be used to understand widely different complex systems. Despite this there have been few applications in medical research.
The hypothesis behind this project is that complexity theory can be used to unravel disease mechanisms and to develop predictive models of complex disease. The models will be validated experimentally and by solving a real-world clinical problem, i.e. to find biological markers for personalized medication. This involves the design, implementation and enhancement of complexity tools (e.g. network theory metrics) used to assess emergent properties from experimental studies of complex diseases, such as allergy, autoimmunity and cancer.
Network theory plays a central role in our approach through the use of separators, connectivity, covers and cliques. Complex diseases are seen from a systems perspective and the focus is on the emergent properties of systems rather than individual components. This involves transfer of knowledge from complexity studies in other fields, such as language evolution. An important feature of the project is that it aims to transfer and develop techniques from complexity science to solve a real-world problem, i.e. to find markers for personalized medication in two different diseases, i.e. allergy and multiple sclerosis.
We believe that this can be achieved within a three-year period and used to promote the science of complexity in medical research. We also want to disseminate analytical tools for such research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine allergology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-NEST-PATH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
100 GÖTEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.