Objective
Our project aims at designing reusable, standardized molecular building blocks that will produce a photosynthetic bacterium containing engineered chemical pathways for competitive, clean and sustainable hydrogen production. Our engineering approach will provide the next generation of synthetic biology engineers with the toolbox to design complex circuits of high potential industrial applications such as the photo-production or photo-degradation of chemical compounds with a very high level of integration.
For this purpose we have targeted on a cyanobacterium, a very chemically rich and versatile organism highly suitable for modeling, to be used as future platform for hydrogen production and biosolar applications. In particular, our synthetic biological approach aims at creating an anaerobic environment within the cell for an optimized, highly active iron-only hydrogenase by using an oxygen consuming device, which is connected to an oxygen sensing device and regulated by artificial circuits. This project will also help to establish a systematic hierarchical engineering methodology (parts, devices and systems) to design artificial bacterial systems using a truly interdisciplinary approach that decouples design from fabrication.
We aim to construct biological molecular parts by engineering proteins with new enzymatic activities and molecular recognition patterns, by combining computational and in-vitro evolution methodologies. Subsequently, we will design novel devices (e.g. input/output, regulatory and metabolic) by combining these parts and by using the emerging knowledge from systems biology. Furthermore, we shall design custom circuits of devices applying control engineering and optimization. In parallel, we will develop a cyanobacterial chassis able to integrate our synthetic circuits using a model-driven biotechnology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences synthetic biology
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology environmental engineering energy and fuels renewable energy hydrogen energy
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering control engineering
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-NEST-PATH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PALAISEAU
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.