Objective
Chromatin is the physiological template of genetic information controlling the capacity of a cell's genome to store, release, and inherit biological information. The basic unit of chromatin is the nucleosome: a stretch of DNA wrapped around a core of histone proteins. Post-translational modifications of histones have emerged as key in regulating chromatin structure and dynamics and are thought to crucially control genome activity. Whereas correlative studies have begun to establish links between several states of chromatin, various histone modifications, and diverse biological processes, our knowledge of how certain histone modifications exert their biological effects on a molecular level is extremely limited.
One of the principles emerging from our previous studies is that certain histone marks are acting via the recruitment of sequence and modification specific binding proteins (effectors). To get a detailed understanding of the signalling principles within the histone modification/effector protein-signalling network, we propose the reconstitution of complex chromatin systems in vitro. In particular, we intend to analyse the readout and the chromatin effects of three intriguing histone methyl-lysine marks (H3 Lys 9, H3 Lys 27, and H4 Lys 20) that have distinct cellular functions and might work via recruitment of HP1 (heterochromatin protein 1), Pc (Polycomb) and MBT (malignant brain tumour) proteins, respectively. We anticipate that our studies will result in a detailed understanding of fundamental "epigenetic" regulatory pathways that cause inheritable changes in gene function and expression, but do not involve changes in DNA sequence.
We believe that the implications of the proposed research could be far reaching as it is becoming clear that many human disease-states, and in particular cancer have an epigenetic component. This estimation is substantiated by the high promise of experimental drugs targeting histone-modifying enzymes in the treatment of human tumours.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.