Objective
Samarium(II) iodide is an extremely versatile reagent in synthetic organic chemistry. Of particular interest are electron-transfer reactions to carbonyl compounds, which provide ketyls capable of undergoing inter- and intramolecular additions to unsaturated groups.
Recently in the group of Prof. Reissig a novel intramolecular reaction involving aryl groups has been discovered, which afforded highly substituted hexahydronaphthalene derivatives with excellent diastereoselectivities. The research proposal deals with the corresponding samarium(II) iodide induced intramolecular reaction of ketyls derived from cyclic ketones with naphthyl substituents or related bicyclic (hetero)aryl groups.
They should lead to tetracyclic products with steroid-like structure and azasteroid derivatives. Scope and limitations of these reactions will be studied as well as the features which influence the stereochemistry of the processes. An extension to enantioenriched precursor compounds is planned, which should be available by asymmetric deprotonation and subsequent alkylation, and finally afford enantioenriched products.
Due to the high degree of functionalisation the products may be further transformed into a variety of products of high interest because of their potential biological activity. Thus, high product diversity may be achieved within a few steps.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.