Objective
Epithelia are potentially vulnerable to infection and environmentally induced mutation. Although there unwell-established ideas for how the immune system may protect epithelia, they fail to mention intraepithelialymphocytes (ells) that are one of the largest T cell compartments. Gamma delta cells contribute to a large part to these ells. The properties of gamma delta cells seem to place them midway the adaptive and innate immune response.
The host laboratory has recently obtained evidence that gamma delta ells provide bothimmunoprotection and immunoregulation within epithelia: this proposal asks how. There are two aims: in the first, candidate genes will be identified by comparative Serial Analysis of Gene Expression (SAGE); in the second the contribution of particular genes to IEL activities in vitro and in vivo will be examined (e.g. by RNA interference).The results should provide a much-improved understanding of epithelial immunosurveillance.The experience profile of David Vermilion (e.g. NK cell background, experiences with ransoms, confocalmicroscopy and apoptosis assays) can clearly add value to the applied project. Equally clear are the benefits for David Vermilion to be gained from his participation in the proposed project Gamma delta cells andimmunosurveillance. He will be trained in advanced techniques like SAGE, he will learn to work with knockout animal models and he will acquire the RNA interference technique. Thus the experience of David Vermilion on the one hand and the training possibilities offered at the Laboratory of Adrian Heyday on the other hand, are complementary. This will result in a synergistic effect and therefore enhance the scientific excellence of the European Union.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.