Objective
Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in human cancer, occurring in over 40% of all cases of cancer. One well-studied outcome of these mutations is the loss of the tumor suppressor activity of the wild type (wt) p53. However, there is growing evidence that many of the mutations that occur in the p53 protein in fact generate mutant p53 proteins (mutp53) that have acquired new biochemical and biological properties. Through this gain of function (GOF), mutp53 is believed to contribute actively to the cancer process. We propose to explore mutp53 as a target for novel anti-cancer therapies. Such therapies should aim to either abrogate the GOF effects of mutp53, or restore wt-like properties to mutp53, so that it can now regain its tumor suppressor capabilities. To achieve these ambitious aims, we propose a multi- disciplinary approach to explore and exploit the contribution of mutp53 to cancer. One component of this project will investigate in depth the molecular properties of mutp53: structural studies will pinpoint the changes that particular mutations inflict on the structure of p53, and allow the classification of mutp53 into distinct subclasses. In parallel, biochemical studies will explore the mode of action of mutp53 within cells, including its impact on patterns of gene expression, identification of specific DNA sequences targeted by mutp53, and discovery of mutp53-interacting cellular proteins. Preclinical models for mutpS 3-driven cancer will also be developed, as a critical instrument for pre- clinical studies. The other component will aim at translating this wealth of information into better cancer therapy. One part ofthat effort will address the clinical relevance of particular p53 mutations in human cancer, and particularly its impact on the patient s response to chemotherapy. This should lead to guidelines for more effective use of conventional therapy.#
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.