Objective Diagnosis and treatment of brain tumours is based on clinical symptoms, radiological appearance, and often a histopathological diagnosis of a biopsy. However, treatment response of histological or radiologically similar tumours can vary widely, particularly for childhood tumours. New technologies are available that may improve tumour classification in terms of diagnosis and prognosis, and may allow individually optimised treatments.Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique for determining tissue biochemicals (the metabolomic profile). MRS can be performed along with clinical MR Imaging but widespread use is hampered by specialised analysis requirements and poor dissemination of the skills needed to interpret the data. The genomic profile of tumours can be determined with DNA microarrays. Early studies have demonstrated differences in gene expression between tumour grades and between tumour types not easily distinguished by morphologic appearance.We will bring together the expertise required to study the genomic and metabolomic characteristics of brain tumours, with a multi-centre collaboration to acquire statistically significant data, particularly for rare tumour types. Clinical MRS, high-resolution 1H MRS and gene array analysis of biopsies, will be used to investigate how metabolomic and genomic profiles relate to clinically relevant factors such as survival time and treatment response. As well as providing new scientific data on tumour biology, we will develop the technology for this information to be readily and easily used to help radiologists and neurosurgeons in the management and treatment of brain tumour patients. We will build upon expertise obtained with INTERPRET EU project IST-1999-10310, which created a MRS decision support tool (DSS) for tumour diagnosis. A new web-accessible DSS will be developed, incorporating genomic and metabolomic data, and its diagnostic performance validated. Fields of science natural sciencescomputer and information sciencessoftwarenatural sciencesbiological sciencesgeneticsDNAnatural sciencescomputer and information sciencesartificial intelligencepattern recognitionengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingnatural sciencesphysical sciencesopticsspectroscopy Keywords DNA micro arrays DSS GUI HR HR-MAS of biopsies MAS of biopsies molecular imaging Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.2.0-5 - Molecular imaging for early detection of tumours and monitoring of treatment Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme IP - Integrated Project Coordinator UNIVERSITAT DE VALENCIA - ESTUDI GENERAL Address Avda. blasco ibañez, 13 Valencia Spain See on map Links Website Opens in new window EU contribution € 0,00 Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all BRUKER BIOSPIN SA. France EU contribution € 0,00 Address 34 rue de l'industrie Wissembourg cedex See on map Links Website Opens in new window DEUTSCHES KREBSFORSCHUNGSZENTRUM Germany EU contribution € 0,00 Address Im neuenheimer feld 280 Heidelberg See on map Links Website Opens in new window FUNDACIÓN PARA LA LUCHA CONTRA ENFERMEDADES NEUROLÓGICAS DE LA INFANCIA Argentina EU contribution € 0,00 Address Montañeses 2325 Ciudad autonoma de buenos aires See on map Links Website Opens in new window HOSPITAL SANT JOAN DE DÉU Spain EU contribution € 0,00 Address Passeig sant joan de déu, 2 Esplugues de llobregat (barcelona) See on map Links Website Opens in new window HYPERPHAR GROUP SPA Italy EU contribution € 0,00 Address Via pascoli 60 Milan See on map Links Website Opens in new window INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE France EU contribution € 0,00 Address Rue de tolbiac 101 Paris See on map Links Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 0,00 Address Oude markt 13 Leuven See on map Links Website Opens in new window MEDICAL UNIVERSITY LODZ Poland EU contribution € 0,00 Address Kosciuszki, 4 Lodz See on map Links Website Opens in new window MICROART, S.L. Spain EU contribution € 0,00 Address Viladomat, 291 Barcelona See on map Links Website Opens in new window PHARMA QUALITY EUROPE, S.R.L. Italy EU contribution € 0,00 Address Via dei poggi, 1 Catelfranco di sopra (arezzo) See on map Links Website Opens in new window SCITO S.A. France EU contribution € 0,00 Address 5 place robert schuman Grenoble See on map Links Website Opens in new window SIEMENS AG, MEDICAL SOLUTIONS Germany EU contribution € 0,00 Address Henkestrasse 127 Erlangen See on map Links Website Opens in new window ST GEORGE'S HOSPITAL MEDICAL SCHOOL' United Kingdom EU contribution € 0,00 Address Cranmer terrace London See on map Links Website Opens in new window STICHTING KATHOLIEKE UNIVERSITEIT Netherlands EU contribution € 0,00 Address Geert grooteplein 10 Nijmegen See on map Links Website Opens in new window THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 0,00 Address University park Nottingham See on map Links Website Opens in new window UNIVERSIDAD POLITÉCNICA DE VALENCIA Spain EU contribution € 0,00 Address Camino de vera s/n Valencia See on map Links Website Opens in new window UNIVERSITAT AUTÒNOMA DE BARCELONA Spain EU contribution € 0,00 Address Campus universitat autònoma de barcelona Bellaterra (cerdanyola des vallès) See on map Links Website Opens in new window UNIVERSITY OF BIRMINGHAM United Kingdom EU contribution € 0,00 Address Edgbaston Birmingham See on map Links Website Opens in new window