Objective
Intracellular communication in eukaryotes is largely achieved by the trafficking of membranes carrying membrane-bound and/or intravesicular signalling molecules.Inside cells, vesicles circulate from one intracellular compartment to another thus facilitating vectorial transport of signals.Between cells, membrane anchored and secreted soluble molecules mediate extracellular signalling.Exocytosis and endocytosis of receptors control the response of sensitive cells to extracellular signals.The routes of membrane trafficking are controlled by cell signalling pathways but the underlying molecular machinery is scarcely characterised. Moreover, membrane trafficking has been studied mainly in differentiated cells and rarely in cells changing phenotype during differentiation or dedifferentiation.Such drastic phenotypic changes occur during development when cells mature to differentiated cells as complex as neurons, and during malignant transformation.The goal of this STREP is to establish the connections between signalling pathways and membrane trafficking in the context of migrating, dividing and adhering mammalian cells.Through the study of membrane traffic in the course of cell differentiation, dedifferentiation, and during mitosis, we aim to unravel how important signalling pathways remodel the intracellular trafficking routes and conversely,how membrane traffic can influence signalling cascades.We will take advantage of several cellular models including neurons differentiating in culture and cancer cells dividing and migrating. We will investigate proteins that play central roles in membrane trafficking and secretion such as rabs,SNAREs and their partners. We will focus on the trafficking of signalling molecules including cell-cell and cell-substrate adhesion molecules, growth factors and their receptors, and also investigate the role of glycosylation. Through these approaches we will define the connections between Signalling and Traffic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences clinical medicine physiotherapy
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.