Objective
The European Cancer Proteases Consortium (EUCPC) proposes multidisciplinary research into innovative approaches for cancer therapy and diagnosis based on the DEGRADOME - the repertoire of extracellular proteases through which cells regulate their local environment. Extracellular proteases remain an attractive target for intervention against cancer, even if first generation anti-protease drugs were disappointing in clinical trials. We now appreciate that proteases have complex roles with distinct functions at different stages of tumour development and progression, and may have conflicting effects on malignancy. We now propose to put these recent insights into pre-clinical and clinical settings. Using four common human malignancies - breast, prostate, colorectal and skin cancer - the EUCPC will employ a combination of strategies involving cell and mouse models, patient tissues, molecular profiling and modelling techniques, as well as physical and molecular imaging of tumours using MRI and PET. The 28 academic and 5 SME Participants combine expertise in genomics, bioinformatics, protein-protein interactions, proteomics, gene expression, molecular diagnostics and pathology, knockout mice and mouse models of cancer, synthetic chemistry, protein structure, drug development and tumour imaging. The EUCPC will facilitate access to shared technologies, data analysis and knowledge dissemination. In this 4 year Integrated Project the EUCPC aims to: 1) Define new molecular targets for drug design. 2) Develop novel specific interventions that are based on thorough knowledge of the pathophysiological roles of target proteases and related molecules, and understand how and when to use them. 3) Identify new molecular diagnostic and prognostic indicators of patient risk that can improve health care delivery based on an individualized, patient-oriented approach to therapy. 4) Provide new ways to enhance visualization of tumours in the clinic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine oncology skin cancer
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NORWICH
United Kingdom
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Participants (35)
COPENHAGEN
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MILAN
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LIÈGE
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OVIEDO
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CAMBRIDGE
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STOCKHOLM
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PARIS
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LEUVEN
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TURKU
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VIENNA
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ATHENS
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STOCKHOLM
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79106 FREIBURG
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141 LJUBLJANA
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MILAN
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HEIDELBERG
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GLASGOW
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10142 IIIKIRCH
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MÜNCHEN
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MARTINSRIED
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101949 HEIDELBERG
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AARHUS C
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NAPOLI
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NAPLES
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MADRID
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LONDON
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LIEGE
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ORSAY
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GENT
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NOVO MESTO
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BASEL
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BERLIN
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SOUTHAMPTON
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Electrum KISTA
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MUNCHEN
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