Objective
With a global incidence increasing at 2% and two million deaths each year, tuberculosis (TB) demands the highest priority among communicable diseases linked to poverty. In developing countries, the vast majority of the TB cases affect the young adult population, increasing its economic impact. The TB-VAC project aims to develop improved vaccines, particularly for the young adult population. Vaccine candidates and strategies will be optimized for evaluation in Phase I clinical trials. TB-VAC consists of two tracks. Track 1. Optimisation of existing vaccine candidates towards Phase I trials.This track is composed of a strategic research component (WP1, 4 and 5) and a down stream development component (WP6). The strategic research focuses on goal-oriented research to optimize delivery and composition of during FP5 selected, promising candidate vaccines (eg, 72F, Hyb-1,85A) and on identification of correlates of protection and markers of TB disease for monitoring of future clinical trials. The downstream development component will carry out GMP production of optimised vaccine candidates, establish pre-clinical files and carry out Phase I clinical trials in European and TB-endemic countries. According to the results, the Consortium will decide upon a strategy to exploit this portfolio. Track 2. Discovery of new vaccine/antigens (WP2 and 3). This track will carry out innovative back-up research to identify and develop novel vaccines/antigens. In WP3, we will focus on subunit vaccines based on dormancy related antigens. In WP2, we proposes to optimise three selected live vaccine candidates that during FP5 showed improved efficacy as compared to BCG and show promise as vaccines in infants. Thirty institutions will participate at the start of this effort including two vaccine producers. Subcontracting will likely involve SMEs. Joint parnerships and funding of GMP production with MUVAPRED will exist.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LELYSTAD
Netherlands
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Participants (34)
RIXENSART
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COPENHAGEN
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1005 ADDIS ABABA
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PARIS
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LUEBECK
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ERLANGEN
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101062 MUENCHEN
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ROME
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PALERMO
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BP 7325 DAKAR
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ZAROGOZA
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BELLINZONA
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GENEVA
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BASEL
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BH-19 LAUSANNE
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PARIS
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9600 LEIDEN
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3306 RIJSWIJK
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LONDON
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BIRMINGHAM
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BIRMINGHAM
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MANCHESTER
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LONDON
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SOUTH MIMMS
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OXFORD
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LONDON
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SALISBURY
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HANNOVER
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RONDEBOSCH
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ULM
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PARIS
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MUNCHEN
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BRUSSELS
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