Objective
The atherosclerotic disease is the final outcome of a complex process, which begins with the oxidation follow density lipoproteins (LDL). The oxidised LDL accumulates in the arterial wall triggering a localinflammatory/proliferative process, in which different types of cells take active part: lymphocytes, monocytes/macrophages, smooth muscle cells (SMC), endothelial cells and platelets. Secretary phospholipaseA2 type II (sPLA2) is among the proteins known to modify the Ladles. This enzyme not only is able to do it, butt has been found in high levels associated to the atherosclerotic plaques. High levels of circulating enzyme have also been found in cardiovascular disease patients, as well as in several other inflammatory pathologies. Even though sPLA2 has been considered a risk marker in the coronary disease, the mechanisms that involve this enzyme in inflammatory processes and its relationship with cardiovascular diseases remain unclear. Therefore, the main aim of this project is to unravel the implication of the sPLA2 in the vascular biology and atherosclerotic events. Based on the recent description of an specific sPLA2 receptor in monocots and considering the enzyme as a signalling molecule, we propose the characterization of its involvement in the immune and inflammatory response that take place in arteriosclerosis. We want to study and analyse the signalling pathways regulated by sPLA2, making a special stress on the small Teases, as well as the implication of the receptor-mediated response. For that purpose a knock down system of the receptor will be set-up. Once defined, the study will concentrate on the pharmacological modulation of the pathways triggered bysPLA2.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine pathology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.