Objective
The ZF-MODELS IP will produce knowledge and technology in the form of disease models,drug targets and insight into pathways of gene regulation applicable to human development and disease.It will achieve these aims by combining the advantages of the zebrafish in developmental biology with recent advances in functional genomics and with the zebrafish genome sequence to harvest large data sets on gene functions.This will include the first integrated use of several newly developed tools on a massive scale: (1) Mutagenesis screening for new phenotypes of medical interest, in particular in adult fish, will identify novel genes (forward genetics). (2) Analysis of expression patterns by GFP enhancer trap and in situ screening will provide qualitative gene expression data and cell type specific material for quantitative analysis. (3) Expression profiling and proteomics analysis of mutant and knock-down conditions will provide quantitative data and let us model regulatory pathways. (4) A virtual European centre for targeted knock-out will provide mutant phenotypes of identified candidate genes (reverse genetics). (5) All project data will be integrated in a European zebrafish database that will present an unprecedented view of gene expression in vertebrate development, and let us apply this knowledge to human health. (6) We will establish a European Working Group on Vertebrate Models to integrate and strengthen research in the field in the ERA. ZF-MODELS will: (1) promote world class research in this key priority area of comparative genomics of clinical relevance, (2) provide the tools necessary to researchers to increase the understanding of the basic mechanisms of major human diseases, (3) bring together the leading European research groups and develop an interface with clinical researchers seeking to address major diseases, (4) contribute to the competitiveness of the pharmaceutical industry in Europe by enabling the development of improved herapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences databases
- social sciences other social sciences development studies social developments
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MÜNCHEN
Germany
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Participants (18)
LONDON
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10142 ILLKIRCH
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85164 UTRECHT
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SHEFFIELD
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LONDON
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7800 BERGEN
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NEUHERBERG
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PARIS
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9503 LEIDEN
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ZURICH
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KARLSRUHE
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DRESDEN
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400195 CHARLOTTESVILLE, VA
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FREIBURG
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PARIS
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DRESDEN
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PADOVA
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ZURICH
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