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CELLS INTO ORGANS: FUNCTIONAL GENOMICS FOR DEVELOPMENT AND DISEASE OF MESODERMAL ORGAN SYSTEMS

Objective

New approaches to treating disease are set to revolutionise health care. Cancers will increasingly be treated by targeted molecules, not cytotoxic drugs. Manipulating stem cells for cell and tissue replacement therapies holds great promise for treatment of degenerative disease and injury. Both approaches depend critically on detailed knowledge of molecular and cellular events governing normal differentiation of target organs and tissues. This knowledge provides the basis for organ and tissue engineering. Very important life threatening or disabling diseases affect mesodermal organ systems. Heart failure and strokes resulting from atherosclerosis, kidney failure, muscular dystrophy, osteoporosis, tumours and leukaemia are caused either by defects in embryonic development of mesoderm containing organ systems or their function.. These diseases represent the principal obstacles to reaching a healthy old age. This proposal contributes to the knowledge base on which new diagnostic and therapeutic approaches will be based. We will elucidate molecular and cellular processes underlying embryonic specification and differentiation of mesodermal organs. It is clear that many developmental master genes later have key roles in regulating function and that cancers abusively reactivate developmental subroutines. We integrate established methodologies of developmental genetics and experimental embryology with sophisticated modern cell biology and new methodologies of genome scale analysis enabled by genome sequencing. The new technologies will reveal many genes which function in building a specific organ system or in directing a particular aspect of embryogenesis. Analysing these genes, investigating their functions, and placing them in developmental cascades as well as following the cells they affect, will reveal new aspects of organ development, extending and completing existing knowledge.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

LEIDEN UNIVERSITY
Address
Rapenburg 70
Leiden
Netherlands

Participants (15)

ERASMUS UNIVERSITY MEDICAL CENTER
Netherlands
Address
Dr. Molewaterplein 50
Rotterdam
THE CHANCELLOR, MASTERS & SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Firth Court, Western Bank
Sheffield
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower St.
London
INSTITUT PASTEUR
France
Address
25, Rue Du Dr Roux
Paris
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan
INSTITUTO GULBENKIAN DE CIENCIA/ FUNDACAO CALOUSTE GULBENKIAN
Portugal
Address
Rua Da Quinta Grande, 6
Oeiras
MAX PLANCK GESELLSCHAFT
Germany
Address
Hofgartenstr. 8
München
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GES. M.B.H., RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY
Austria
Address
Dr Bohr-gasse 7
Vienna
BIOZENTRUM, UNIVERSITY OF BASEL
Switzerland
Address
Klingelbergstrasse 70
Basel
UNIVERSITY OF GENEVA
Switzerland
Address
30, Quai Ernest-ansermet
Genève 4,
ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES
Netherlands
Address
Kloveniersburgwal 29
Amsterdam
INSTITUTO DE MEDICINA MOLECULAR
Portugal
Address
Edificio Egas Moniz, Av. Prof. Egas Moniz
Lisbon
CENTRE DE MEDICINA REGENERATIVA DE BARCELONA
Portugal
Address
Doctor Aiguader 88
Barcelona
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III
Spain
Address
C/melchor Fernández Almagro, 3
Madrid