Objective
New approaches to treating disease are set to revolutionise health care. Cancers will increasingly be treated by targeted molecules, not cytotoxic drugs. Manipulating stem cells for cell and tissue replacement therapies holds great promise for treatment of degenerative disease and injury. Both approaches depend critically on detailed knowledge of molecular and cellular events governing normal differentiation of target organs and tissues. This knowledge provides the basis for organ and tissue engineering. Very important life threatening or disabling diseases affect mesodermal organ systems. Heart failure and strokes resulting from atherosclerosis, kidney failure, muscular dystrophy, osteoporosis, tumours and leukaemia are caused either by defects in embryonic development of mesoderm containing organ systems or their function.. These diseases represent the principal obstacles to reaching a healthy old age. This proposal contributes to the knowledge base on which new diagnostic and therapeutic approaches will be based. We will elucidate molecular and cellular processes underlying embryonic specification and differentiation of mesodermal organs. It is clear that many developmental master genes later have key roles in regulating function and that cancers abusively reactivate developmental subroutines. We integrate established methodologies of developmental genetics and experimental embryology with sophisticated modern cell biology and new methodologies of genome scale analysis enabled by genome sequencing. The new technologies will reveal many genes which function in building a specific organ system or in directing a particular aspect of embryogenesis. Analysing these genes, investigating their functions, and placing them in developmental cascades as well as following the cells they affect, will reveal new aspects of organ development, extending and completing existing knowledge.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology muscular dystrophies
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology leukemia
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.