E-MeP's research platform will focus on developing and implementing new technologies to solve the bottlenecks that preclude the determination, at high throughput, of high-resolution structures of membrane proteins and membrane protein complexes. This will be achieved by integrating the activities of many of the world leaders in membrane protein structural biology. The E-MeP consortium will develop methods and exchange laboratory and in silico tools aimed at solving the structures of membrane proteins, which comprise more than 30% of known proteomes. Specifically, the heterologous production, purification and crystallisation of a library of bioinformatically-selected membrane proteins will be streamlined by elucidating the parameters responsible for success and failure at each of these key stages. In the process new technologies will be developed and commercialised to overcome existing bottlenecks peculiar to membrane protein structural genomics, which cannot be solved by existing methods. A mobilisation of European expertise to address this timely issue will ultimately contribute to understanding membrane protein-related human diseases.
Fields of science
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Funding SchemeIP - Integrated Project
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