Objective
Nociceptive stimuli are essential in maintaining the integrity of an organism. Certain diseases however generate chronic, pathological pain, which is detrimental to this integrity. P2X ATP receptors are involved in the initiation and transmission of nociceptive signals in peripheral tissues. The host laboratory showed that P2X receptors, as well as GABAA receptors, are involved in a new mechanism modulating nociceptive signals in the spinal cord and that their function can be affected by neurosteroids, a class of steroids produced in the nervous system.
This project aims to
(1) Determine the exact nature of the endogenous neurosteroids involved in nociception and their site of production
(2) Define both the acute and chronic action of these neurosteroids on nociceptive neurotransmission
(3) Determine the nociceptive neuronal subpopulations affected by these neurosteroids
(4) Evaluate the role of neurosteroids in the generation of pathological pain in disease states
We will use a multidisciplinary approach including morphological, electrophysiological and molecular methods applied to in vitro and in vivo models of inflammatory or Neutrogena pain. The results of this project will improve our comprehension of the generation of pathological pain and define the role of neurosteroids in the initiation and maintenance of pain. The neurosteroid modulation mechanism of nociceptive signalling will provide targets for new and innovative therapeutic strategies of chronic pathological pain management that avoid side effects such as addiction and tolerance. This project relies on the synergy of the competences of both the fellow and the host laboratory. It will result in a two-way knowledge transfer that will enhance both the career prospects of the fellow and the scientific excellence of the host institution and more generally of the European scientific community. The new concepts developed will provide new opportunities for European pharmaceutical industries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine pharmacology and pharmacy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STRASBOURG
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.