DNA-based biophysics and biotech
European researchers initiated the ‘Control of assembly and charge transport properties of immobilized DNA’ (CIDNA) project in order to apply imaging technology of extremely high spatial and temporal resolution to study charge transfer through immobilised DNA. Scientists carried out detailed charge transfer studies including structural nuclear magnetic resonance (NMR) imaging as well as advanced computational modelling. Results led to the most detailed understanding to date of charge transfer mechanisms in immobilised DNA structures. CIDNA researchers described conformational changes in DNA controlled by an electrochemical potential with the help of in situ scanning tunnelling microscopy (STM). Four patents were filed and results were disseminated not only through typical scientific channels but to young students as well as through high school teaching to stimulate interest in science. Detailed understanding of immobilisation of DNA structures on solid supports enabled control of ensemble and single-molecule activity and the most thorough description of charge transfer to date. Undoubtedly, the growing field of DNA chip technology has benefited greatly from CIDNA’s accomplishments.
