Objective
How do we smell? The main aim of this proposal is to contribute to the understanding of how odor information from the environment is perceived. Recent experiments have focused on spatial aspects of olfactory coding in the olfactory bulb and have shown that all the olfactory sensory neurons expressing one odorant receptor gene, from a family of 1000, converge into a few glomeruli. However, temporal aspects of response to odorants may play a very important role in olfactory coding in mammals. Therefore, we propose to measure the temporal patterns of mitral cell responses to odorants. A major innovative aspect of this proposal is the use of a multidisciplinary approach, in wich electrophysiological measurements of mitral cell activity will be made in gene-targeted mice, in which all lofactory sensory neurons that express a chosen odorant receptor gene also produce the green fluorescent protein. The use of these gene-targeted mice will allow to visually identify the glomeruli by using green fluorescent protein. The use of these gene-targeted mice will allow to visually identify the glomeruli. Recordings will be made by using odorants known to activate the chosen receptor. Various odorant concentrations and exposure times will be used. The results will provide new information on temporal aspects of olfactory coding. Dr. Giulietta Pinato, recipient of a EU Marie Curie Individual Fellowship, has acquired expertise in electrophysiological recordings from granule and mitral cells in the olfactory bulb in the laboratory of Prof. Midtgaard, Denmark, and would like to return to her home country, Italy, and carry on the proposed project in the laboratory of Prof. Anna Menini, an intenational leader in the field of olfaction. A European Reintegration Grant will be of great help for the development of Dr. Pinato research career, by placing her recently developed expertisse within the framework of a coherent of a coherent research project on the olfactory system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TRIESTE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.