Objective
There is much interest on whether some individuals are more genetically susceptible than others to developing lung cancer. Genetic polymorphisms in genes involved in the metabolism of tobacco, DNA repair, cell cycle control, and nicotine addiction are ca ndidate to determine such a susceptibility. A tool to study the genetic susceptibility is to carry out case-control association studies with a high quality information on lifestyle and to have high-throughput technologies for genotyping a broad selection of genes. During the MCF fellowship period, we set up an oligonucleotide micro-array based on arrayed primer extension technology (APEX) that allows the parallel high-throughput genotyping of 158 single nucleotide polymorphisms in 51 candidate genes. T he genes are reported as follows: ADH1B, ALDH2, APE1, CDKN2A, COMT, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, DRD2, DRD4, EPHX1, ERCC1, ERCC2, ERCC4, ERCC5, GRPR, GSTA2, GSTA4, GSTM1, GSTM3, GSTP1, GSTT2, LIG3, MDM2, MGMT, MnSOD2, MPO, MPC, MTHFR, NATI, NAT2, NQO1, OGGI, CDKN1A, PCNA, POLB, SLC6A3, SULT1A1, TP53, TPMT, UGT1A7, XRCC1, XRCC2, XRCC3, XRCC9. We called this microarray \"MetaboChip\" and we have already validated it by genotyping a standard reference sample se t (SNP500 from NCI). Now, we are aiming to use MetaboChip to genotype a cohort of DNA samples (310 patients, 310 controls) who are part of a larger multicentric case-control study. To better investigate the role of genetics, we will focus on patients who developed the disease before the age of 50 years. Most of the polymorphisms included in MetaboChip are demonstrated to have a biological significance and the study will allow testing hypothesis of the interaction between tobacco-smoke and genotypes (hyp othesis testing). Moreover, part of the SNPs will be just explored, as there is not information about their functional role.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences genetics nucleotides
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PISA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.