Objectif
Diseases of the kidney represent a major cause of morbidity and mortality in Europe. The elderly are disproportionately affected, but renal disease is also a condition that severely affects children. An estimated 4.5 Million Europeans suffer from renal disorders. The death rate in patients with renal failure is 20% annually. This disease burden and its challenge for our societies is the focus of this proposal. Elucidation of the human and other genomes heralds a new era in biomedical research offering unprecedented opportunities to understand disease processes and to identify strategies to improve health. We will embrace these opportunities and implement an interdisciplinary research program, the European Renal Genome Project (EuReGene) that integrates European excellence in research relevant to renal development, pathophysiology and genetics. Our goal is to discover genes responsible for renal development and disease, their proteins and their actions. To achieve this goal, we have established a consortium of leading scientists, clinicians and SME partners that will focus on the development of novel technologies and discovery tools in functional genomics and their application to kidney research. We will rely on comparative genomic studies in many systems that provide utilitarian models ranging from zebrafish, to Xenopus, to mice, to rats. Our studies will be performed at different levels including the gene, the cell, the organ and the organism. Ultimately, identification of disease genes will lead to a better understanding of renal disease processes, to improved diagnosis and to new concepts in therapy. Our program will establish a paradigm for an integrated post-genomic approach to analyze renal disease-related developments that may be transferred to other organ systems or disease entities in the future.
Champ scientifique
- medical and health sciencesclinical medicineendocrinologydiabetesdiabetic nephropathy
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicineembryology
- medical and health sciencesclinical medicinenephrologykidney diseases
Mots‑clés
Appel à propositions
FP6-2003-LIFESCIHEALTH-I
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Régime de financement
IP - Integrated ProjectCoordinateur
740238 BERLIN
Allemagne