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Psychobiology of posttraumatic stress disorder

Objective

Post-traumatic stress disorder (PTSD) is the most common war-related psychiatric disorder occurring among combat veterans and other people exposed to war-zone stress. Current opinion is that the best results in PTSD understanding, diagnosis and treatment could be achieved by integrating psychological, biological and pharmacotherapeutical approaches.General objective of this project is to better understand the psychobiological basis of PTSD. The study will focus on establishing multiple correlations of d ifferent PTSD subtypes with relevant psychological, biochemical, endocrinological, genetic, physiological and anthropometric parameters. Five groups of subjects will be studied: a) patients with war-zone related PTSD, b) patients with war-zone related PTS D in remission, c) war-zone exposed subjects without PTSD, d) healthy controls from Western Balkans and e) healty controls from Western Europe. Subjects in these groups will be male. Psychological assessment will be performed on four analogous groups of female subjects. Psychological assessments include psychometrics, neuropsychological testing and personality assessment. Biological measurements will encompass parameters related to hypothalamo-pituitary-adrenocortical axis (including cortisol receptor a nd its gene polymorphism), anthropometry, body composition, lipid status, insulin resistance, and sleep disturbances. This study will yield new knowledge on relations between: a) basic psychological variables and PTSD, b) biological variables and PTSD, a nd c) biological and basic psychological variables in health and in PTSD. In addition, the foreseen benefits of the project include: d) development of combined psycho-biological batteries for PTSD screening, diagnosing and risk factors assessing, e) impr ovement of psychological instruments for measuring PTSD, and f) implementation of new biological markers for PTSD

Call for proposal

FP6-2002-INCO-WBC-1
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITY MEDICAL CENTER UTRECHT
Address
Heidelberglaan 100
Utrecht
Netherlands

Participants (8)

INSTITUTE FOR BIOLOGICAL RESEARCH "SINISA STANKOVIC"
Address
29Th November 142
Belgrade
INSTITUTE OF ENDOCRINOLOGY, DIABETES & METABOLIC DISEASE
Address
Dr Subotica 13
Belgrade
INTERNATIONAL AID NETWORK
Address
Admirala Geprata 10
Belgrade
MILITARY MEDICAL ACADEMY
Address
Crnotravska 17
Belgrade
QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON
United Kingdom
Address
Mile End Road
London
SCHOOL OF MEDICINE UNIVERSITY OF RIJEKA
Croatia
Address
Brace Branchetta 20
Rijeka
SPECIALIZATION SCHOOL OF PSYCHIATRY - DEPARTEMENT OF NEUROLOGY AND PSYCHIATRIC SCIENCES - UNIVERSITY OF BARI - ITALY
Italy
Address
Policlinico - Piazza Giulio Cesare N. 11
Bari
VINCA INSTITUTE OF NUCLEAR SCIENCES
Address
No Street Name
Belgrade