Objective Post-traumatic stress disorder (PTSD) is the most common war-related psychiatric disorder occurring among combat veterans and other people exposed to war-zone stress. Current opinion is that the best results in PTSD understanding, diagnosis and treatment could be achieved by integrating psychological, biological and pharmacotherapeutical approaches.General objective of this project is to better understand the psychobiological basis of PTSD. The study will focus on establishing multiple correlations of d ifferent PTSD subtypes with relevant psychological, biochemical, endocrinological, genetic, physiological and anthropometric parameters. Five groups of subjects will be studied: a) patients with war-zone related PTSD, b) patients with war-zone related PTS D in remission, c) war-zone exposed subjects without PTSD, d) healthy controls from Western Balkans and e) healty controls from Western Europe. Subjects in these groups will be male. Psychological assessment will be performed on four analogous groups of female subjects. Psychological assessments include psychometrics, neuropsychological testing and personality assessment. Biological measurements will encompass parameters related to hypothalamo-pituitary-adrenocortical axis (including cortisol receptor a nd its gene polymorphism), anthropometry, body composition, lipid status, insulin resistance, and sleep disturbances. This study will yield new knowledge on relations between: a) basic psychological variables and PTSD, b) biological variables and PTSD, a nd c) biological and basic psychological variables in health and in PTSD. In addition, the foreseen benefits of the project include: d) development of combined psycho-biological batteries for PTSD screening, diagnosing and risk factors assessing, e) impr ovement of psychological instruments for measuring PTSD, and f) implementation of new biological markers for PTSD Fields of science natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicinepsychiatryposttraumatic stress disordersocial sciencessociologysocial issuessocial inequalitiesnatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Keywords Cortisol receptor HPA PTSD endoopiates personality psychological dissociation stress syndrome X Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) INCO-2002-C.2.1 - Post-conflict and post-trauma Call for proposal FP6-2002-INCO-WBC-1 See other projects for this call Funding Scheme IP - Integrated Project Coordinator UNIVERSITY MEDICAL CENTER UTRECHT Address Heidelberglaan 100 Utrecht Netherlands See on map Links Website Opens in new window EU contribution € 0,00 Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE FOR BIOLOGICAL RESEARCH "SINISA STANKOVIC" EU contribution € 0,00 Address 29th november 142 Belgrade See on map INSTITUTE OF ENDOCRINOLOGY, DIABETES & METABOLIC DISEASE EU contribution € 0,00 Address Dr subotica 13 Belgrade See on map INTERNATIONAL AID NETWORK EU contribution € 0,00 Address Admirala geprata 10 Belgrade See on map MILITARY MEDICAL ACADEMY EU contribution € 0,00 Address Crnotravska 17 Belgrade See on map Links Website Opens in new window QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON United Kingdom EU contribution € 0,00 Address Mile end road London See on map Links Website Opens in new window SCHOOL OF MEDICINE UNIVERSITY OF RIJEKA Croatia EU contribution € 0,00 Address Brace branchetta 20 Rijeka See on map SPECIALIZATION SCHOOL OF PSYCHIATRY - DEPARTEMENT OF NEUROLOGY AND PSYCHIATRIC SCIENCES - UNIVERSITY OF BARI - ITALY Italy EU contribution € 0,00 Address Policlinico - piazza giulio cesare n. 11 Bari See on map Links Website Opens in new window VINCA INSTITUTE OF NUCLEAR SCIENCES EU contribution € 0,00 Address No street name Belgrade See on map Links Website Opens in new window
