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Content archived on 2024-06-18

The development of a chairside diagnostic biomarker assay to assess metabolic activity with inflammatory diseases

Objective

The project is concerned with the development of a chairside immunoassay for the detection and quantitation of biomarkers indicating inflammatory and jawbone destruction in dentistry. Specific bone matrix proteins have been identified in gingival crevicula r fluid (serum based fluid collected about teeth) in clinical conditions where active resorption of tooth supporting bone is highly probable and thus proposed as ideal biomarkers to determine the health status of deep unseen dental tissues. The assay consi dered in the project is the first prototype of a new line of diagnostic products to be developed jointly by the participants. The assay to be developed is noninvasive and aims at measuring the marker in crevicular fluid collected at tooth base on paper str ips. The immunoassay will use coloured nanoparticles for its development so that it can be read by the dental surgeon at the patient's side. The test is expected to offer more relevant information on the pathological process than currently available diagno stic procedures, allowing for quicker therapeutic handling. The test will be developed jointly by the Dental School at the University of Wales College of Medicine which identified and purified the marker, and Englebienne and Associates, a Belgian SME spe cialised in developing rapid diagnostic tests. For the project purpose, a post-doctoral student from the academic partner (who has an understanding of teeth supporting tissues and biomarkers in health and disease) will be hosted by the SME for training dur ing active product development. They will then assist in clinical validation co-ordinated by the academic partner. In the longer term, the collaboration established is intended to secure the shared development and commercialisation by the participants of a complete line of diagnostic immunoassay products for dentistry and stomatology. The project also intends to create the basis for a European centre of excellence in dental diagnostics benefiting society at large.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2002-MOBILITY-3
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

TOK - Marie Curie actions-Transfer of Knowledge

Coordinator

UNIVERSITY OF WALES COLLEGE OF MEDICINE
EU contribution
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Address
Health Park Cardigan House
CARDIFF
United Kingdom

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (1)

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