Objective
Inhibition of new blood vessel formation is a promising therapy against cancer, diabetic retinopathy, or rheumatoid arthritis where pathological angiogenesis occurs. However, as shown by the failure of some angiogenesis inhibitors in clinical trials, the m olecular mechanisms of angiogenesis are still elusive and more effective and fine-tuned therapies for angiogenic diseases are awaited. New evidence indicates that angiotensin II, generated by angiotensin converting enzyme (ACE), contributes to the progress ionof diabetic retinopathy and some cancers. The precise role of the renin-angiotensin pathway in angiogensis is unknown. Josef Penninger's laboratory recently identified a novel homologue of ACE, termed ACE-2. In genetic experiments his group showed that ACE2 is a candidate QTL for hypertensions and that loss of ACE2 results in heart failure and decreased heart functions (Crackower et al. Nature 2002). These data provided the first genetic evidence that the renin-angiotensin system has a critical and direc t role in the heart and introduced a novel paradigm for negative regulation of the renin-angiotensin pathway, i.e. ACE2 counterbalances the function of ACE. The goal of this proposal is to identify the role of ACE-family molecules ACE, ACE2, and collectrin and their vasoactive peptide substrates such as angiotensin II in angiogenesis and to develop novel therapeutic strategies to modulate new blood vessel formation in disease. We propose to investigate angiogenesis in knockout mice of ACE, ACE2 and collectr in as well as mice that have mutations in the ACE/ACE2 substrates angiotensinogen, apelin, and bradykinin using murine angiogenesis models. We hypothesize that adult angiogenesis in mammals is conserved in primitive vascular development in fruitfly, since a P-element mutation associated with the Drosophila ACE/ACE2 homologue ACER results in defective heart tube formation. To elucidate yet unknown substrate peptides and/or #'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- medical and health sciences clinical medicine ophthalmology retinopathy
- medical and health sciences clinical medicine cardiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.