Objective
Blood coagulation factor XIII (FXIII) is a heterotetramer consisting of two potentially active A subunits and two protective/inhibitory B subunits. Activated form of the zymogen is a transglutaminase, which forms isopeptide crosslinks between two polypepti de chains. Main physiological function of FXIII is to stabilize fibrin by crosslinking its chains and to protect fibrin from the powerful fibrinolytic machinery. Inherited deficiency of FXIII result in severe bleeding tendency. During the the activation of plasma FXIII first thrombin cleaves the activation peptide of the N-terminal of FXIII-A, then if Ca2+ is present, the B subunits dissociate from the A subunits and the active-site cysteine becomes available. Synthesis site for FXIII-A is in the components of monocyte/macrophage system and in the megakaryocytes. FXIII-B is synthesized in the liver. The only known biological function of FXIII-B is the binding of FXIII-A. FXIII-B has a typical domain structure, it is composed of so-called Sushi domains. Prote ins containing Sushi domains are involved in protein-protein binding, like the different components of the complement system. Binding of the two subunits of FXIII is important to maintain the stability of FXIII-A in blood plasma environment. Without FXIII-B, FXIII-A is unstable in the blood plasma. Hardly anything is known about the details of the binding of the two subunits. The resistance and stability of the fibrin clot is a central issue for the clot lysis therapies. Therefore, the ability to influence FXIII activity can be very beneficial. Fine tuning of the level of circulating FXIII-A by specific blocking peptides or monoclonal antibodies might result in more lysable fibrin clot which can be of a great importance in the treatment of thrombosis. The go al of this application would be to identify the possible binding domain(s) on FXIII-B involved in the binding to FXIII-A with the help of immunological, molecular biological, and biochemical methods.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DEBRECEN
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.