Objective
Mature red blood cells are highly specialised for oxygen transport throughout the body but carry also sex hormones in the bloodstream. Several examples are known about modification of some functions and properties of red cells as well as regulation of their production in the presence of sex steroids. However, the exact molecular mechanisms whereby action of these compounds is mediated are remained largely unclear. In the present project the potential physiological role of sex hormones and their derivatives on survival of mature red blood cells will be screened in a systematic and comprehensive way and signalling mechanisms of these effects will be further examined. As erythrocytes are enucleated cells the classical genomic pathway of steroids action via intra-cellular receptors can be excluded.
On the other hand, knowledge of rapid non-genomic responses to steroids mediated probably by specific membrane proteins are too recent and no data about possible involvement of membrane receptors in processes regulated b y sex hormones in red blood cells are available so far. Therefore, in this work the action mechanisms of sex steroids in erythrocytes will be studied in detail by analysing the effects of these hormones on different second messenger cascades. Also the pharmacology and nature of putative membrane binding sites are planned to investigate. The results expected to gain from this work make an important contribution to the issue of use of androgens in stimulation of erythropoiesis in bone marrow failure conditions.
Secondly, this work will probably lead to some new knowledge about the positive and negative side effects associated with changes in the level of sex hormones in blood. Third, the results of this project can also bring about some improvements in clinical treatment schemes by recommendation of administration of steroid derivatives in certain types of red cell pathologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine pharmacology and pharmacy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TARTU
Estonia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.