Objective
The development of neural circuitry is a vastly complex process, and the role of many of its components - notably the control of neuronal morphology, the formation of specific synaptic connections as well as the exquisite localisation of key synaptic proteins - is still very poorly understood. In this frame the present project aims to reach a more comprehensive understanding of cortical networking during development and in particular of genes and their products governing the complex molecular mechanisms driving synaptic structuring and organisation during development of cortical networks and circuitries. This project will integrate the information about the role of different candidate genes/proteins in synaptic formation, remodelling and function and it will capitalise on results obtained in in vitro systems and translate them to clinic al application. The final aim is to identify key steps responsible for defect of development associated to mental retardation. Since intellectual performances are directly related to brain development and plasticity of excitatory synapses and these are generally located in cortical neurons, the project will focus primarily on these structures. The proteins that will be identified as important factors in the development of functional synapses will then be studied for their implications in the development of synaptic dysfunctions using different animal genetic models of mental retardation. Thus the project will: i) characterise gene products responsible for synapse formation and function ii) assess the role of mutation/deletion of selected genes in synaptic function in in vitro systems and in intact organisms iii) analyse the impact of mutations of scaffolds in driving mental retardation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.