Objective
In December 2002,Science magazine selected small Ranks with regulatory function as the scientific breakthrough of the year. Small Ranks play a hitherto unrecognized critical regulatory role in controlling gene expression at different levels in a variety of organisms across kingdoms. The number of small non-coding RNAs discovered in recent years is in a range of one thousand. In a fundamental genomics approach this consortium aims to-wards advancement of knowledge on how regulatory RNAs are integrated into the general network of gene expression. Evolutionary aspects will be addressed to obtain a broad and integrated understanding of riboregulators. Thus, organisms from different kingdoms (eubacteria, protists, plants and animals) will be investigated, along with various classes of regulatory RNAs (microRNAs, snoRNAs, bacterial small RNAs). Molecular targets will be identified and characterised and the expression patterns of target and regulatory RNA monitored under various environmental or developmental conditions. We will develop bioinformatic tools by designing new algorithms for the in silico prediction of RNA targets. A special focus will be directed towards small RNAs from pathogenic bacteria and on human small RNAs that are implicated in human diseases, including common forms of cancer. Research on both these topics should generate vital knowledge applicable for future therapeutic intervention. Multi-protein complexes and other protein components will be studied that are required for the generation or function of small RNAs and that are of potential biotechnological interest. Finally, we will study structural and functional aspects of small RNAs to elucidate mechanisms of interaction with the targets. The experimental strategies will pursue multidisciplinary approaches (gene expression, proteomics, bioinformatics) and make use of sophisticated instrumentation, such as scanning force microscopy, surface plasma resonance, and microcalorimetry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences evolutionary biology
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UPPSALA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.