Objective
Although peroxisomes are essential for life,the various functions and dynamics of this organelle in health and disease are only poorly understood.Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormo us burden on affected individuals,families and society.A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies.To bridge the gap between the scarce knowledge about peroxisomes and their impor tance for living organisms,we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes.We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions.Using this informat ion,we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of per oxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed.Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood.Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance,such as arteriosclerosis,cancer and Alzheimer's disease,we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins.Tissue micr oarray analysis,cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools.The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered.Only with this integrated ED project we will be able to elucidate the role of peroxisomes in living organisms in the near future.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine hepatology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.