Integrated project to decipher the biological function of peroxisomes in health and disease

Project Information

PEROXISOMES

Grant agreement ID: 512018

Start date 1 January 2005

End date 31 December 2008

Funded under

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Total cost € 8 209 434,00

EU contribution € 8 000 000,00

Coordinated by

MEDICAL UNIVERSITY OF VIENNA (MEDIZINISCHE UNIVERSITAT WIEN)
Austria

Objective

Although peroxisomes are essential for life,the various functions and dynamics of this organelle in health and disease are only poorly understood.Most inherited peroxisomal disorders in humans have a low incidence but collectively they represent an enormo us burden on affected individuals,families and society.A detailed understanding of biogenesis and function of this organelle is required for developing therapeutic strategies.To bridge the gap between the scarce knowledge about peroxisomes and their impor tance for living organisms,we will establish genomic, proteomic and metabolomic platforms focussed on peroxisomes.We will identify novel peroxisomal matrix and membrane proteins and gather comprehensive knowledge about their functions.Using this informat ion,we should be able to decipher the molecular mechanism of so far uncharacterised peroxisomal disorders and open up novel diagnostic and therapeutic opportunities. Genome-wide gene expression and biochemical analyses of 14 different mouse models of per oxisomal deficiencies will reveal why differing phenotypes occur even when the same metabolic pathway is disturbed.Mouse genetics will be used to evaluate the role of peroxisomes in different cell types during development and in adulthood.Because evidence is emerging for a role of peroxisomes as modulators in diseases of complex inheritance,such as arteriosclerosis,cancer and Alzheimer's disease,we will screen appropriate databases to detect dysregulation of genes encoding peroxisomal proteins.Tissue micr oarray analysis,cDNA chip and quantitative RT-PCR analysis will be used to verify the results with the final goal to develop diagnostic tools.The role of peroxisomes in Alzheimer's disease and in chronic metabolic liver diseases will be analysed and the biogenesis and dynamics of this organelle deciphered.Only with this integrated ED project we will be able to elucidate the role of peroxisomes in living organisms in the near future.'

Fields of science

• medical and health sciences › basic medicine › neurology › dementia › alzheimer
• natural sciences › computer and information sciences › databases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › hepatology

Keywords

• Diagnosis
• Genomics
• Human Diseases
• Mouse Models
• Peroxisome
• Proteomics
• Therapy

Programme(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

• LSH-2003-1.1.5-2 - Functional genomics approaches to the study of peroxisomes in health and disease

Call for proposal

FP6-2003-LIFESCIHEALTH-I
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

MEDICAL UNIVERSITY OF VIENNA (MEDIZINISCHE UNIVERSITAT WIEN)

• EU contribution: No data
• Address: Spitalgasse 23 ; VIENNA ; Austria
• Total cost: No data

Participants (14)

ACADEMIC MEDICAL CENTER BY THE UNVERSITY OF AMSTERDAM

Netherlands

• EU contribution: No data
• Address: Meibergdreef 9 ; AMSTERDAM
• Total cost: No data

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

• EU contribution: No data
• Address: Oude Markt 13 ; LEUVEN
• Total cost: No data

RUHR-UNIVERSITAT BOCHUM

Germany

• EU contribution: No data
• Address: Universitatsstr. 150 ; BOCHUM
• Total cost: No data

RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG, BIOCHEMIE-ZENTRUM

Germany

• EU contribution: No data
• Address: Seminarstrasse 2 ; HEIDELBERG
• Total cost: No data

UNIVERSITY OF VIENNA, DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY

Austria

• EU contribution: No data
• Address: Dr. Karl Lueger-Ring 1 ; VIENNA
• Total cost: No data

UNIVERSITE DE BOURGOGNE

France

• EU contribution: No data
• Address: Maison de l'Universite, Esplanade Erasme, Maison de l'Universite ; DIJON
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. INSTITUTE FOR EXPERIMENTAL MEDICINE

Germany

• EU contribution: No data
• Address: Hofgartenstrasse 8 ; MUENCHEN
• Total cost: No data

UNIVERSITY OF L'AQUILA, DEPARTMENT OF BASIC AND APPLIED BIOLOGY

Italy

• EU contribution: No data
• Address: Piazza V. Riviera 1 ; L'AQUILA
• Total cost: No data

UNIVERSITY OF OULU

Finland

• EU contribution: No data
• Address: Pentti Kaiterankatu 1 ; OULU
• Total cost: No data

KAROLINSKA INSTITUTET

Sweden

• EU contribution: No data
• Address: Nobels vag 5 ; STOCKHOLM
• Total cost: No data

ORIDIS BIOMED FORSCHUNGS- UND ENTWICKLUNGS GMBH - PARTICIPATION TERMINTED 12/31/2006

Austria

• EU contribution: No data
• Address: Elisabethstrasse 84/1 ; GRAZ
• Total cost: No data

MEDIZINISCHE UNIVERSITAT GRAZ (MEDICAL UNIVERSITY OF GRAZ)

Austria

• EU contribution: No data
• Address: Universitatsplatz 3 ; GRAZ
• Total cost: No data

UNIVERSITEIT GENT

Belgium

• EU contribution: No data
• Address: Sint-Pietersnieuwstraat 25 ; GENT
• Total cost: No data

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR

Portugal

• EU contribution: No data
• Address: Rua do Campo Alegre, 823 ; PORTO
• Total cost: No data