Skip to main content
European Commission logo
español español
CORDIS - Resultados de investigaciones de la UE
CORDIS
Contenido archivado el 2024-05-29

A multidisciplinary approach to determine the structures of protein complexes in a model organism

Objetivo

Progress of modern day biology will require understanding and harnessing the network of interactions between genes, proteins and the functional systems that these produce. Given the complexity of even the most primitive living organism, and our still very limited knowledge, it is unreasonable to expect that we might, in the near or even medium term, reach such understanding at the level of an entire cell. A prequesite for this goal is an understanding of the biological function of the complete set of genes and proteins within genomes (post-genomic biology). Proteins rarely act alone: they typically interact with other macromolecules to perform particular cellular tasks. The resulting functional assemblies (complexes) are more than the sum of their parts. They have a function that is not easily understood by even the most systematic analyses of single proteins. Thus the discovery and analysis of particular cellular protein complexes under physiological conditions provides key insights into their function, and takes the characterisation of the system well beyond the limits of other experiments. Prominent examples include the ribosome, the chaperonin GroEl/GroEs, the spliceosome, the cyclosome, the proteasome, the nuclear pore complex and the synaptosome. Analyses of results from genome- scale interaction discoveries in yeast show a clear tendency for many yeast assemblies to mirror their equivalents in animals, including the model organisms and man. Complexes essential for the cell overlap significantly, and represent the building blocks of a Eukaryotic core proteome covering basic cellular function. More importantly, those conserved between yeast and man will contribute significantly to the understanding of multifactorial diseases, particularly those related to key cellular processes. Elucidation of three-dimensional (3D structures for protein complexes will open new avenues to unravel the molecular pathology and physiology...

Ámbito científico

Programa(s)

Tema(s)

Convocatoria de propuestas

FP6-2003-LIFESCIHEALTH-I
Consulte otros proyectos de esta convocatoria

Régimen de financiación

NoE - Network of Excellence

Coordinador

CENTRE DE REGULACIÓ GENÒMICA
Aportación de la UE
Sin datos
Dirección
Carrer Doctor Aiguader, 88
BARCELONA
España

Ver en el mapa
Enlaces
Coste total
Sin datos

Participantes (19)

Compartir esta página

Descargar

Última actualización: 26 Marzo 2013

Mi folleto

Permalink: https://cordis.europa.eu/project/id/512028/es

European Union, 2024