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Molecular phenotyping to accelerate genomic epidemiology

Objective

Epidemiologists, clinical trialists and experimental scientists are confronted with a wealth of potential opportunities for molecular phenotyping large numbers of biological samples obtained from cohorts, patients or animal models. The challenge now is to ensure that these tools are developed to permit high-throughput analyses of significant numbers of samples, cohort protocols are in place for sample collection and storage, and that systems are in place to capture, warehouse and analyse the range of biolog ical data that will emerge from these studies. This consortium will bring some of these tools into practice during the course of the next four years so that they can be used to identify biomarkers that predict disease, determine risk and relate to disease activity or response to therapy. The programme is divided into three parts: 1. The evaluation of sample collection and storage methodology to optimally sample variation and disease analyte stability. 2. The development of tools for molecular phenotyping at epidemiologic scale including measuring small molecules (metabonomics), mRNA in white blood cells (transcription profiling, protein and peptide analysis using mass spectrometry methodology, affinity arrays and tissue arrays, DNA methdylation patterns and genetics. 3. The development of bioinformatic tools for data warehousing, data interrogation and statistical analysis in large sample sets. 4. The consortium will adopt two separate approaches (i) genome wide, systematic methodology (metabonomics, ms based metanomics) and (ii) limited analysis using sets of candidate biomarkers (transcipt profiling, methylation, affinity arrays, tissue arrays) Collectively, these programmes bring together the necessary skills and tools to allow moleculear phenotyping to be realistically applied, informing our study of common disease and its treatment.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Coordinator

THE CHANCELLORS, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
University Offices, Wellington Square
Oxford
United Kingdom

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Participants (20)

AFFIBODY AB
Sweden
Address
Voltavagen 13
Bromma

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BIOVISION AG
Germany
Address
Feodor-lynen-str. 5
Hannover

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CHARLES UNIVERSITY, THIRD FACULTY OF MEDICINE
Czechia
Address
Ruska 87
Prague

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COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Batiment Le Ponant D - 25 Rue Le Blanc
Paris

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CONSORTIUM NATIONAL DE RECHERCHE EN GENOMIQUE
France
Address
2 Rue Gaston Crémieux
Evry

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DIGILAB BIOVISION GMBH
Germany
Address
C/o Nörr Stiefenhofer Lutz, Brienner Str. 28
München

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EPIGENOMICS. AG
Germany
Address
Kastanienalle 34
Berlin

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EUROPEAN MOLECULAR BIOLOGY LABORATORY.
Germany
Address
Meyerhofstrasse 1
Hiedelberg

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F. HOFFMANN LA ROCHE AG
Switzerland
Address
Grenzacherstrasse Building 93/8.34
Basel

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GUYS AND ST THOMAS HOSPITAL NHS TRUST
United Kingdom
Address
Lambeth Palace Road
London

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GYROS AB
Sweden
Address
Uppsala Science Park
Uppsala

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IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
South Kensington Campus
London

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INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101, Rue De Tolbiac
Paris

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INSTITUTE OF MATHEMATICS AND COMPUTER SCIENCE, UNIVERSITY OF LATVIA
Latvia
Address
Rainis Bouevard 29
Riga

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KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London

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KUNGLIGA TEKNISKA HÖGSKOLAN
Sweden
Address
Valhallavägen 79
Stockholm

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NOVO NORDISK A/S
Denmark
Address
Novo Alle 6a1.027
Bagsvaerd

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OXFORD GENE TECHNOLOGY (OPERATIONS) LTD
United Kingdom
Address
Begbroke Business And Science Park, Sandy Lane
Yarnton, Oxford

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UNIVERSITY OF PAVIA (UNIVERSITA DI PAVIA)
Italy
Address
Via Bassi, 21
Pavia

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UPPSALA UNIVERSITY
Sweden
Address
Rudbeck Laboratory
Uppsala

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