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Content archived on 2024-06-25

Congenital disorders of glycosylation: a European network for the advancement of research, diagnosis and treatment of a growing group of rare disorders

Objective

The Congenital Disorders of Glycosylation (CDG) are an emerging group of inborn errors of metabolism. Most of these genetic defects result in severe disease, mental retardation and physical handicap. EUROGLYCANET will promote (early) diagnosis by offering the diagnostic tools for screening as well as for expert analysis and by raising awareness. It will integrate research activities in the field, and work towards the development of therapies for CDG and related disorders. To fulfil these aims, EUROGLYCANET will 1) develop and share effective tools for (early) and expert diagnosis and 2) manage a sample flow through the different laboratories involved in this activity; 3) maintain a database, accessible through Internet and a public website. EUROGLYCANET will also raise awareness by 4) providing information to the public and to physicians and other professionals, and by 5) offering training to expert clinicians and researchers in the field. To foster research it will select interesting cases for research and 6) establish an international research forum, including biennial internationalcongresses, where clinical and basic scientists will meet. The coordinated diagnostic and research activities include a.o. applications of DNA-arrays, 2-D gels, mass spectrometry and capillary electrophoresis for the study of glycoproteins and glycolipids synthesis and defects, and the development and use of yeast and mouse models for the study of the pathogenesis and the evaluation of therapies. 7) The network will promote collaborations with companies for the development of therapeutics. The integration of clinical and basic research groups within the network is a strong advantage in this respect. EUROGLYCANET will 8) increase quality and standardization by offering QA schemes and 9) spread and promote access to diagnostic services by installing additional referral centers in different European countries...

Fields of science (EuroSciVoc)

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Keywords

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Topic(s)

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Call for proposal

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FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

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NoE - Network of Excellence

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
EU contribution
No data
Address
Oude Markt 13
LEUVEN
Belgium

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (27)

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