Objective
Lyme Borreliosis is the most common tick-borne infection in Eurasia, large parts of China, Japan, and North America. The disease manifests itself as a multi-system disorder, which can affect a complex range of tissues including the skin, musculoskeletal system, heart, and nervous system, leading to arthritis, carditis, and neuroborreliosis. The availability of the complete genome sequence from Borrelia burgdorferi has enabled the search for antigens and vaccine candidates among the complete proteome of this pathogen. This knowledge together with the use of human serum antibodies and whole-genome libraries will be applied to identify the most promising vaccine candidates from Borrelia in a very short time and without the need of expressing a large number of recombinant proteins. Applying the powerful combination of state-of-the-art experimental technologies and bioinformatics, we propose to identify common antigens from Borrelia burgdorferi, gannii and afzeiii, which can function as targets for protective immunity preventing LB and as markers for serodiagnosis. The participating SMEs and RTDs maintain the highest quality of research and technology in their respective field, among them proven and renowned experts of LB and Borrelia. The anticipated results of this project will be of immediate benefit to the involved SMEs. Novel diagnostic markers can be exploited commercially leading to a new standard in clinical diagnosis, whereas a prophylactic vaccine can enter clinical testing after completion of this project. Further benefits include the development of marketable research tools, the creation of international networks and the publication of results in scientific journals. This work will add to the repertoire of intellectual property of the involved SMEs and further broaden the expertise of both, RTDs and SMEs. At last, the project will be of great societal benefit by its contribution to the understanding of the underlying mechanisms of disease caused by Borrelia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine toxicology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.