Objective
Precise knowledge of the three dimensional (3D) structure of a given protein forms the basis of understanding its mechanism of action. Such knowledge is particularly important for designing and developing new drugs, but is also essential to understand the biology of humans and of other organisms. The HUGO-project has determined the complete human genome where the focus has now shifted from the DNA level to the structure and function of gene products at the protein level. An important method for protein structure determination is X-ray crystallography. The method requires access to single protein crystals, which has been the primary limiting step. This project aims to complete development of LEVMAC, a piece of equipment used in the field of Proteomics - to assist the crystallization of macromolecular structures, especially to resolve difficult cases where crystals of protein-ligand complexes are sought by the pharmaceutical industry. We will refine the prototype LEVMAC into an affordable and user-friendly instrument with good accuracy and validity, and with adequate software support. The LEVMAC device will be implemented in the frontline structural studies of naked and enveloped viruses, membrane receptor proteins, and protein-ligand complexes - areas in focus for advanced Proteomics and drug discovery. The equipment will allow structure determination of macromolecules to be reached faster and with higher accuracy than earlier, and at the same time waste less of precious macromolecular materials. To support these goals, the underlying algorithms for defining crystallization conditions will be further explored to provide nucleation phase diagrams. There is no competing equipment. Thus, the interest in the LEVMAC is expected to be very high among the pharmaceutical industries and within the scientific community. The proposed project will put CRAB at the forefront in the international Proteomics race and substantially benefit to the other participants as well.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.