The aim of this project is to develop new vaccination approaches for the highly needed treatment of lung cancer. Lung carcinoma is the number one killer amongst cancer patients, for which no adequate treatment exists. With conventional therapy, median survival for the subtype of small cell lung cancer (SCLC) is 15 months for limited-stage disease and 9 months for extensive-stage disease, whereas long-term survival is very low.
Major obstacles to the successful treatment and eradication of lung cancer are late diagnosis, highly metastatic behaviour, resistance to chemotherapy and the impossibility to surgically remove all cancer cells. In principle, cancer vaccines are a most promising approach for the treatment of cancer in general and lung cancer in particular. Major obstacles in the development of a successful vaccine are the lack of cancer specific antigens to be targeted and the lack of tools to evaluate immunotherapy based on such targets.
Call for proposal
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