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Development of Innovative immuno-PCR assay for the detection and quantification of ochratoxin and aflatoxin in complex matrices (milk, coffee)

Objective

Ochratoxin A (OTA) is a mycotoxin produced by several fungi of the Pnicillium and Asper-giUus species. Aflatoxin is produced by at least three species of Aspergillus, A. flavus, A. parasiticus, A. nominus. They occur naturally in a variety of plant products such as cereals, coffee, wine, beer and spices. OTA has been proved to have carcinogenic, nephrotoxic, teratogenic, immunotoxic and possibly neurotoxic properties and has been linked to nephropathy in humans.

Aflatoxins have sub-acute and chronic effects in humans like primary livercancer, chronic hepatitis, jaundice, hepatomegaly and cirrhosis. Aflatoxin Mt is an hydroxylated metabolite produced when ruminants ingest contaminated feed. It is excreted in milk and may subsequently contaminate other dairy products such as cheese and yoghurt, which represents an important risk factor for frequent consumers, in particular for infants and young children. After cereal products, coffee and beer contribute about 15 %to OTA ingestion.

Call for proposal

FP6-2002-SME-1
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Coordinator

VEREIN ZUR FÖRDERUNG DES TECHNOLOGIETRANSFERS AN DER HOCHSCHULE BREMERHAVEN E.V.
Address
An Der Karlstadt 10
Bremerhaven
Germany

Participants (8)

BIOCULT BV
Netherlands
Address
Niels-bohrweg 11-13
Leiden
BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES S.A.
Spain
Address
C/valle De Tobalina 52 Nave 43
Madrid
CHIMERA BIOTECH GMBH -
Germany
Address
Fischkai 1
Bremerhaven
FUNDACION GAIKER
Spain
Address
Parque Tecnologico De Zamudio, Edificio 202.
Zamudio
ISEAO TECHNOLOGIES LTD
United Kingdom
Address
Riverbank House, 1 Putney Bridge Approach
London
LÖFBERGS LILA AB
Sweden
Address

Karlstad
MUNGIVET S.L.
Spain
Address
Artiz Bidea 18B
Mungia-bizkaia
UNIVERSITY OF STRATHCLYDE
United Kingdom
Address
Richmond Street 16
Glasgow