Final Activity Report Summary - COMPUT. ALDOLASES (Computer aided investigation of aldolase reactivity and stereoselectivity. Modelling of new mutated enzymes)
The aim of this project was to study the mechanism of an enzyme (an aldolase) that is used by a collaborative group to synthesise potential drugs. By understanding the molecular tricks that the enzyme uses we will be able to predict when it will be more or less proficient when given different molecules. And even better, with the help of molecular biology tools, we can build modified or mutated enzymes that will excel in the synthesis of the particular family of molecules that we are interested in.